Studying microbial evolution

through computation, experiment, and theory

 

Welcome to the Baym Lab at Harvard Medical School, started in July 2017!

The lab The lab in June 2019

Antibiotic resistance is one of the defining public health threats of our time. Every time a new antibiotic has been introduced, resistance rapidly follows. We study how resistance evolves with the goal of making practical interventions that take into account, and even anticipates, pathogen evolution. This relies on both experimental recapitulation of the process of resistance evolution as well as the study of genomic data from real-world infections.

More broadly, antibiotic resistance provides an excellent model system for evolution. In a sense, we as a society have been performing a directed evolution experiment in pathogens on a worldwide scale. Only now, with rapid sequencing, is the technology becoming available to understand the results.

Or, to describe what we do in Up Goer Five terms:

Very small living things that can not be killed hurt more and more people each year. People used to find many ways to kill them, but it is getting harder to find new ones that work. We study how the small things change over time to avoid being killed by us. We use this to find approaches to fighting the small things which expect these changes and change with them. We try to make approaches that can be used by doctors to keep killing the small things and to keep them from hurting people.

Our research is supported by the David and Lucile Packard Foundation and the NIH NIGMS.

Lab News

October 2019: Eve's Thesis wins "Best Master Thesis in Life Sciences and Technology" at EPFL! Congratulations, Eve!

September 2019: Siân and Natalia are contributing authors on The fitness landscape of the African Salmonella Typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid in PLOS Pathogens

July 2019: The lab has been awarded a MIRA/R35 Outstanding Early-Stage Investigator Award by NIH/NIGMS! 🎉🎉🎉

July 2019: Michael contributes to Cell Host and Microbe's Voices on overcoming antibiotic resistance: Sustainable Stewardship Needs Evolution

July 2019: Eve presents a poster at the Microbial Population Biology Gordon Research Conference.

June 2019: Siân presents three talks and two posters at ASM Microbe, and wins a travel award! Wow.

June 2019: Mische joined the lab as a summer undergrad

May 2019: Elle joined the lab as a summer undergrad

March 2019: Natalia passed her quals. Congratulations, Natalia!

February 2019: Anurag passed his quals. Congratulations, Anurag!

February 2019: Cristina speaks at ASLO 2019 in Puerto Rico

October 2018: The lab has been awarded a 2018-2023 Packard Fellowship!